If you wish to disable those key combinations while your application is running call SystemKeys. When you call SystemKeys, if Disable is True, the keys will be disabled, False otherwise.
Note: the code does NOT work under Win NT systems (XP, 2000)
procedure SystemKeys(Disable: Boolean) ;
var OldVal : LongInt;
begin
SystemParametersInfo(SPI_SCREENSAVERRUNNING, Word(Disable), @OldVal, 0) ;
end;